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Page 1
A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production.
Keeler SP, Wu K, Zhang Y, Mao D, Li M, Iberg CA, Austin SR, Glaser SA, Yantis J, Podgorny S, Brody SL, Chartock JR, Han Z, Byers DE, Romero AG, Holtzman MJ. Keeler SP, et al. Am J Physiol Lung Cell Mol Physiol. 2023 Dec 1;325(6):L726-L740. doi: 10.1152/ajplung.00183.2023. Epub 2023 Oct 17. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 37847710
Our previous work identified a related but distinct kinase known as MAPK13 that is activated in respiratory airway diseases and is required for mucus production in human cell-culture models. Support for MAPK13 function in these models came from effectiveness of M …
Our previous work identified a related but distinct kinase known as MAPK13 that is activated in respiratory airway diseases and is re …
A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production.
Keeler SP, Wu K, Zhang Y, Mao D, Li M, Iberg CA, Austin SR, Glaser SA, Yantis J, Podgorny S, Brody SL, Chartock JR, Han Z, Byers DE, Romero AG, Holtzman MJ. Keeler SP, et al. bioRxiv [Preprint]. 2023 Oct 4:2023.05.26.542451. doi: 10.1101/2023.05.26.542451. bioRxiv. 2023. PMID: 37292761 Free PMC article. Updated. Preprint.
Our previous work identified a related but distinct kinase known as MAPK13 that is activated in respiratory airway diseases and is required for mucus production in human cell-culture models. Support for MAPK13 function in these models came from effectiveness of M …
Our previous work identified a related but distinct kinase known as MAPK13 that is activated in respiratory airway diseases and is re …
Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis.
Zheng L, Han X, Hu Y, Zhao X, Yin L, Xu L, Qi Y, Xu Y, Han X, Liu K, Peng J. Zheng L, et al. Pharmacol Res. 2019 Jan;139:431-439. doi: 10.1016/j.phrs.2018.11.040. Epub 2018 Nov 29. Pharmacol Res. 2019. PMID: 30503840
Furthermore, miR-351-5p mimic and inhibitor experiments in IEC-6 cells further proved that dioscin up-regulated MAPK13 expression by decreasing miR-351-5p level to inhibit inflammation and apoptosis. Therefore, dioscin showed protective effect against II/R injury vi …
Furthermore, miR-351-5p mimic and inhibitor experiments in IEC-6 cells further proved that dioscin up-regulated MAPK13 expression by …
TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia.
Lee JW, Nam H, Kim LE, Jeon Y, Min H, Ha S, Lee Y, Kim SY, Lee SJ, Kim EK, Yu SW. Lee JW, et al. Autophagy. 2019 May;15(5):753-770. doi: 10.1080/15548627.2018.1556946. Epub 2018 Dec 13. Autophagy. 2019. PMID: 30523761 Free PMC article.
Macroautophagy/autophagy is a lysosome-dependent catabolic process for the turnover of proteins and organelles in eukaryotes. Autophagy plays an important role in immunity and inflammation, as well as metabolism and cell survival. Diverse immune and inflammatory signals in …
Macroautophagy/autophagy is a lysosome-dependent catabolic process for the turnover of proteins and organelles in eukaryotes. Autophagy play …
MicroRNA-351-5p aggravates intestinal ischaemia/reperfusion injury through the targeting of MAPK13 and Sirtuin-6.
Hu Y, Tao X, Han X, Xu L, Yin L, Sun H, Qi Y, Xu Y, Peng J. Hu Y, et al. Br J Pharmacol. 2018 Sep;175(17):3594-3609. doi: 10.1111/bph.14428. Epub 2018 Jul 26. Br J Pharmacol. 2018. PMID: 29952043 Free PMC article.
Also, miR-351-5p markedly reduced MAPK13 level, activated polycystic kidney disease 1/NF-kappaB signal and increased NF-kappaB (p65). ...CONCLUSIONS AND IMPLICATIONS: Our data showed that miR-351-5p aggravated II/R injury by promoting intestinal mucosal oxidative stress, …
Also, miR-351-5p markedly reduced MAPK13 level, activated polycystic kidney disease 1/NF-kappaB signal and increased NF-kappaB (p65). …
p38γ and p38δ modulate innate immune response by regulating MEF2D activation.
Escós A, Diaz-Mora E, Pattison M, Fajardo P, González-Romero D, Risco A, Martín-Gómez J, Bonneil É, Sonenberg N, Jafarnejad SM, Sanz-Ezquerro JJ, Ley SC, Cuenda A. Escós A, et al. Elife. 2023 Jul 17;12:e86200. doi: 10.7554/eLife.86200. Elife. 2023. PMID: 37458356 Free PMC article.
Evidence implicating p38gamma and p38delta (p38gamma/p38delta) in inflammation are mainly based on experiments using Mapk12/Mapk13-deficient (p38gamma/deltaKO) mice, which show low levels of TPL2, the kinase upstream of MKK1-ERK1/2 in myeloid cells. This could obscu …
Evidence implicating p38gamma and p38delta (p38gamma/p38delta) in inflammation are mainly based on experiments using Mapk12/Mapk13 …
The Role of p38γ in Cancer: From review to outlook.
Xu W, Liu R, Dai Y, Hong S, Dong H, Wang H. Xu W, et al. Int J Biol Sci. 2021 Sep 23;17(14):4036-4046. doi: 10.7150/ijbs.63537. eCollection 2021. Int J Biol Sci. 2021. PMID: 34671218 Free PMC article. Review.
It contains four subtypes in mammalian cells encoded by different genes including p38alpha (MAPK14), p38beta (MAPK11), p38gamma (MAPK12), and p38delta (MAPK13). Recent studies revealed that p38gamma may exhibit a crucial role in tumorigenesis and cancer aggressiveness. ...
It contains four subtypes in mammalian cells encoded by different genes including p38alpha (MAPK14), p38beta (MAPK11), p38gamma (MAPK12), an …
Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38gamma and p38delta, linking inflammation and cancer in colitis-associated colon cancer.
Del Reino P, Alsina-Beauchamp D, Escós A, Cerezo-Guisado MI, Risco A, Aparicio N, Zur R, Fernandez-Estévez M, Collantes E, Montans J, Cuenda A. Del Reino P, et al. Cancer Res. 2014 Nov 1;74(21):6150-60. doi: 10.1158/0008-5472.CAN-14-0870. Epub 2014 Sep 12. Cancer Res. 2014. PMID: 25217523
p38 MAPK signaling has been implicated in the regulation of processes leading to cancer development and progression. Chronic inflammation is a known risk factor for tumorigenesis, yet the precise mechanism of this association remains largely unknown. The related p38alphaMA …
p38 MAPK signaling has been implicated in the regulation of processes leading to cancer development and progression. Chronic inflammation …
Integrated network pharmacology and experimental validation to explore the mechanisms underlying naringenin treatment of chronic wounds.
Sun R, Liu C, Liu J, Yin S, Song R, Ma J, Cao G, Lu Y, Zhang G, Wu Z, Chen A, Wang Y. Sun R, et al. Sci Rep. 2023 Jan 4;13(1):132. doi: 10.1038/s41598-022-26043-y. Sci Rep. 2023. PMID: 36599852 Free PMC article.
Naringenin promoted wound healing in mice in vivo by inhibiting wound inflammation. Furthermore, in vitro experiments showed that a low naringenin concentration did not significantly affect normal skin cell viability and cell apoptosis; a high naringenin concentration was …
Naringenin promoted wound healing in mice in vivo by inhibiting wound inflammation. Furthermore, in vitro experiments showed that a l …
Purification and characterization of a serine protease from organic dust and elucidation of its inductive effects on lung inflammatory mediators.
Kusampudi S, Meganathan V, Keshava S, Boggaram V. Kusampudi S, et al. Am J Physiol Lung Cell Mol Physiol. 2023 Jul 1;325(1):L74-L90. doi: 10.1152/ajplung.00309.2022. Epub 2023 May 30. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 37253661
Our studies have isolated for the first time a trypsin protease from poultry farm dust and have shown that it stimulates lung inflammation. The protease stimulates the production of oxidants and cell signaling pathways to increase inflammatory mediator production. ...
Our studies have isolated for the first time a trypsin protease from poultry farm dust and have shown that it stimulates lung inflammatio …
24 results